Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage

Incomplete APOBEC3G/F neutralization by a defective HIV-1Vif protein can promote genetic diversification by inducing G-to-A mutations in the HIV-1 genome. The HIV-1 Env V3 loop, critical for coreceptor usage, contains several putative APOBEC3G/F target sites. Here, we determined if APOBEC3G/F, in th...

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發表在:Antimicrob Agents Chemother
Main Authors: Alteri, Claudia, Surdo, Matteo, Bellocchi, Maria Concetta, Saccomandi, Patrizia, Continenza, Fabio, Armenia, Daniele, Parrotta, Lucia, Carioti, Luca, Costa, Giosuè, Fourati, Slim, Di Santo, Fabiola, Scutari, Rossana, Barbaliscia, Silvia, Fedele, Valentina, Carta, Stefania, Balestra, Emanuela, Alcaro, Stefano, Marcelin, Anne Genevieve, Calvez, Vincent, Ceccherini-Silberstein, Francesca, Artese, Anna, Perno, Carlo Federico, Svicher, Valentina
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505216/
https://ncbi.nlm.nih.gov/pubmed/26055363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00137-15
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