Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels

The hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels control rhythmicity in neurons and cardiomyocytes. Cyclic AMP allosterically modulates HCN through the cAMP-dependent formation of a tetrameric gating ring spanning the intracellular region (IR) of HCN, to which cAMP bind...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: VanSchouwen, Bryan, Akimoto, Madoka, Sayadi, Maryam, Fogolari, Federico, Melacini, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505013/
https://ncbi.nlm.nih.gov/pubmed/25944904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.651877
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