Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy

BACKGROUND: Stroke immediately sets into motion sustained excitotoxicity and calcium dysregulation, causing aberrant activity in neuronal nitric oxide synthase (nNOS) and an imbalance in the levels of nitric oxide (NO). Drugs targeting nNOS-originated toxicity may therefore reduce stroke-induced dam...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Neurosci
Prif Awduron: Khan, Mushfiquddin, Dhammu, Tajinder S, Matsuda, Fumiyo, Singh, Avtar K, Singh, Inderjit
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502912/
https://ncbi.nlm.nih.gov/pubmed/26174015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-015-0179-x
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