Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy

BACKGROUND: Stroke immediately sets into motion sustained excitotoxicity and calcium dysregulation, causing aberrant activity in neuronal nitric oxide synthase (nNOS) and an imbalance in the levels of nitric oxide (NO). Drugs targeting nNOS-originated toxicity may therefore reduce stroke-induced dam...

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Udgivet i:BMC Neurosci
Main Authors: Khan, Mushfiquddin, Dhammu, Tajinder S, Matsuda, Fumiyo, Singh, Avtar K, Singh, Inderjit
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502912/
https://ncbi.nlm.nih.gov/pubmed/26174015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-015-0179-x
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