Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI

Traumatic brain injury (TBI) derails nitric oxide (NO)-based anti-inflammatory and anti-excitotoxicity mechanisms. NO is consumed by superoxide to form peroxynitrite, leading to decreased NO bioavailability for S-nitrosoglutathione (GSNO) synthesis and regulation of neuroprotective pathways. Neurona...

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Bibliographische Detailangaben
Veröffentlicht in:Brain Res
Hauptverfasser: Khan, Mushfiquddin, Dhammu, Tajinder S, Matsuda, Fumiyo, Annamalai, Balasubramaniam, Dhindsa, Tejbir Singh, Singh, Inderjit, Singh, Avtar K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684819/
https://ncbi.nlm.nih.gov/pubmed/26596859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2015.11.015
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