Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Reducing the levels of these injurious bioactive lipi...

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Bibliographische Detailangaben
Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Khan, Mushfiquddin, Shunmugavel, Anandakumar, Dhammu, Tajinder S, Matsuda, Fumiyo, Singh, Avtar K, Singh, Inderjit
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436116/
https://ncbi.nlm.nih.gov/pubmed/25971887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0311-y
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