Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy

BACKGROUND: Stroke immediately sets into motion sustained excitotoxicity and calcium dysregulation, causing aberrant activity in neuronal nitric oxide synthase (nNOS) and an imbalance in the levels of nitric oxide (NO). Drugs targeting nNOS-originated toxicity may therefore reduce stroke-induced dam...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Neurosci
Auteurs principaux: Khan, Mushfiquddin, Dhammu, Tajinder S, Matsuda, Fumiyo, Singh, Avtar K, Singh, Inderjit
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502912/
https://ncbi.nlm.nih.gov/pubmed/26174015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-015-0179-x
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