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Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

The receptor-associated protein tyrosine kinases JAK1 and JAK2 are both required for the interferon (IFN)-gamma response. The effects of expressing kinase-negative JAK mutant proteins on signal transduction in response to IFN-gamma in wild-type cells and in mutant cells lacking either JAK1 or JAK2 h...

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Udgivet i:EMBO J
Principais autores: Briscoe, J, Rogers, N C, Witthuhn, B A, Watling, D, Harpur, A G, Wilks, A F, Stark, G R, Ihle, J N, Kerr, I M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450278/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8631301/
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