Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

The receptor-associated protein tyrosine kinases JAK1 and JAK2 are both required for the interferon (IFN)-gamma response. The effects of expressing kinase-negative JAK mutant proteins on signal transduction in response to IFN-gamma in wild-type cells and in mutant cells lacking either JAK1 or JAK2 h...

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Main Authors: Briscoe, J, Rogers, N C, Witthuhn, B A, Watling, D, Harpur, A G, Wilks, A F, Stark, G R, Ihle, J N, Kerr, I M
Formato: Artigo
Idioma:Inglês
Publicado: 1996
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC450278/
https://ncbi.nlm.nih.gov/pubmed/8631301
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