A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and activators of transcription) 1 and 3 are activated in response to interleukin-6 (IL-6) in human fibrosarcoma cells. In mutant cells lacking JAK1, JAK2 or Tyk2, the absence of one kinase does not prevent activation of...

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Detalhes bibliográficos
Main Authors: Guschin, D, Rogers, N, Briscoe, J, Witthuhn, B, Watling, D, Horn, F, Pellegrini, S, Yasukawa, K, Heinrich, P, Stark, G R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC398228/
https://ncbi.nlm.nih.gov/pubmed/7537214
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