A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and activators of transcription) 1 and 3 are activated in response to interleukin-6 (IL-6) in human fibrosarcoma cells. In mutant cells lacking JAK1, JAK2 or Tyk2, the absence of one kinase does not prevent activation of...

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Pubblicato in:	EMBO J
Autori principali:	Guschin, D, Rogers, N, Briscoe, J, Witthuhn, B, Watling, D, Horn, F, Pellegrini, S, Yasukawa, K, Heinrich, P, Stark, G R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398228/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7537214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07128.x
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