SIRT5 regulation of ammonia-induced autophagy and mitophagy

In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Polletta, Lucia, Vernucci, Enza, Carnevale, Ilaria, Arcangeli, Tania, Rotili, Dante, Palmerio, Silvia, Steegborn, Clemens, Nowak, Theresa, Schutkowski, Mike, Pellegrini, Laura, Sansone, Luigi, Villanova, Lidia, Runci, Alessandra, Pucci, Bruna, Morgante, Emanuela, Fini, Massimo, Mai, Antonello, Russo, Matteo A, Tafani, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Basic Science Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502726/
https://ncbi.nlm.nih.gov/pubmed/25700560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1009778
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