SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH

Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress. Here, we show that in mammalian cells subjected to hypoxia and staurosporine treatment SIRT3 prevents loss of mitochondrial membrane potential (ΔΨ(mt)), intracellular acidification and reactive oxygen specie...

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Detalhes bibliográficos
Main Authors: Pellegrini, L, Pucci, B, Villanova, L, Marino, M L, Marfe, G, Sansone, L, Vernucci, E, Bellizzi, D, Reali, V, Fini, M, Russo, M A, Tafani, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469066/
https://ncbi.nlm.nih.gov/pubmed/22595756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.62
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