SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH

Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress. Here, we show that in mammalian cells subjected to hypoxia and staurosporine treatment SIRT3 prevents loss of mitochondrial membrane potential (ΔΨ(mt)), intracellular acidification and reactive oxygen specie...

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Detalles Bibliográficos
Autores principales: Pellegrini, L, Pucci, B, Villanova, L, Marino, M L, Marfe, G, Sansone, L, Vernucci, E, Bellizzi, D, Reali, V, Fini, M, Russo, M A, Tafani, M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469066/
https://ncbi.nlm.nih.gov/pubmed/22595756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.62
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