SIRT5 regulation of ammonia-induced autophagy and mitophagy

In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that...

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Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Polletta, Lucia, Vernucci, Enza, Carnevale, Ilaria, Arcangeli, Tania, Rotili, Dante, Palmerio, Silvia, Steegborn, Clemens, Nowak, Theresa, Schutkowski, Mike, Pellegrini, Laura, Sansone, Luigi, Villanova, Lidia, Runci, Alessandra, Pucci, Bruna, Morgante, Emanuela, Fini, Massimo, Mai, Antonello, Russo, Matteo A, Tafani, Marco
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Basic Science Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502726/
https://ncbi.nlm.nih.gov/pubmed/25700560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1009778
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