Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and caspase activation, resulting in cell death. In this study, we demonstrate tha...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Deegan, Shane, Saveljeva, Svetlana, Logue, Susan E, Pakos-Zebrucka, Karolina, Gupta, Sanjeev, Vandenabeele, Peter, Bertrand, Mathieu JM, Samali, Afshin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502706/
https://ncbi.nlm.nih.gov/pubmed/25470234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15548627.2014.981790
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