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Simple downstream process based on detergent treatment improves yield and in vivo transduction efficacy of adeno-associated virus vectors

Recombinant adeno-associated viruses (rAAV) are promising candidates for gene therapy approaches. The last two decades were particularly fruitful in terms of processes applied in the production and purification of this type of gene transfer vectors. This rapid technological evolution led to better y...

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Bibliografske podrobnosti
izdano v:Mol Ther Methods Clin Dev
Main Authors: Dias Florencio, Gabriella, Precigout, Guillaume, Beley, Cyriaque, Buclez, Pierre-Olivier, Garcia, Luis, Benchaouir, Rachid
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502676/
https://ncbi.nlm.nih.gov/pubmed/26207258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.24
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