The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance

Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here we performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT), and serendipitously identified the TMAO-g...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Warrier, Manya, Shih, Diana M., Burrows, Amy C., Ferguson, Daniel, Gromovsky, Anthony D., Brown, Amanda L., Marshall, Stephanie, McDaniel, Allison, Schugar, Rebecca C., Wang, Zeneng, Sacks, Jessica, Rong, Xin, de Aguiar Vallim, Thomas, Chou, Jeff, Ivanova, Pavlina T., Myers, David S., Brown, H. Alex, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Liu, Xiuli, Parini, Paolo, Tontonoz, Peter, Lusis, Aldon J., Hazen, Stanley L., Temel, Ryan E., Brown, J. Mark
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501903/
https://ncbi.nlm.nih.gov/pubmed/25600868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.12.036
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