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Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus

The RF-specific AM14 tg BCR has been used as a model to dissect the mechanisms of B cell tolerance to ICs containing nucleic acids. We have shown previously that AM14 RF B cells break tolerance in the TC mouse model of lupus through the dual engagement of the AM14 BCR and TLR9. In this study, we sho...

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Dettagli Bibliografici
Pubblicato in:J Leukoc Biol
Autori principali: Sang, Allison, Zheng, Ying Yi, Choi, Seung-Chul, Zeumer, Leilani, Morel, Laurence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Leukocyte Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501674/
https://ncbi.nlm.nih.gov/pubmed/25957308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1A1214-576R
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