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Activation of rheumatoid factor-specific B cells is antigen-dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model()
AM14 rheumatoid factor (RF) B cells in the MRL/lpr mice are activated by dual BCR and TLR7/9 ligation and differentiate into plasmablasts via an extrafollicular (EF) route. It was not known whether this mechanism of activation of RF B cells applied to other lupus-prone mouse models. We investigated...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119566/ https://ncbi.nlm.nih.gov/pubmed/25015835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303000 |
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