Activation of rheumatoid factor-specific B cells is antigen-dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model()

AM14 rheumatoid factor (RF) B cells in the MRL/lpr mice are activated by dual BCR and TLR7/9 ligation and differentiate into plasmablasts via an extrafollicular (EF) route. It was not known whether this mechanism of activation of RF B cells applied to other lupus-prone mouse models. We investigated...

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Main Authors: Sang, Allison, Niu, Haitao, Cullen, Jaime, Choi, Seung Chul, Zheng, Ying Yi, Wang, Haowei, Shlomchik, Mark J., Morel, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119566/
https://ncbi.nlm.nih.gov/pubmed/25015835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303000
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