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Glucose oxidation is critical for CD4(+) T cell activation in a mouse model of systemic lupus erythematosus()
We have previously shown that CD4(+) T cells from B6.Sle1.Sle2.Sle3 (TC) lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxyglucose (2DG), which inhibits glucose metabolism, and metformin, which inhibits oxygen consumption, normalized lupus T cell functions...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684991/ https://ncbi.nlm.nih.gov/pubmed/26608911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501537 |
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