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Acetaminophen induces JNK/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug. Generally, the therapeutic dose of APAP is clinically safe, however, high doses of APAP can cause acute liver and kidney injury. Therefore, the majority of previous studies have focussed on elucidating the mechanisms of APAP-induc...

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Detalhes bibliográficos
Publicado no:Int J Mol Med
Principais autores: YIANG, GIOU-TENG, YU, YUNG-LUNG, LIN, KO-TING, CHEN, JEN-NI, CHANG, WEI-JUNG, WEI, CHYOU-WEI
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501662/
https://ncbi.nlm.nih.gov/pubmed/26096646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2015.2254
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