Chemical Probes for the Functionalization of Polyketide Intermediates**

A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S. lasaliensis in the presence of the probes generated a range of unnatural polyk...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Riva, Elena, Wilkening, Ina, Gazzola, Silvia, Li, W M Ariel, Smith, Luke, Leadlay, Peter F, Tosin, Manuela
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2014
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501312/
https://ncbi.nlm.nih.gov/pubmed/25212788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201407448
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