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A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates

A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation. From the lasalocid A polyketide assembly in a mutant strain of the soil bacterium Streptomyces lasaliensis, a previously un...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Kilgour, Samantha L., Jenkins, Robert, Tosin, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972646/
https://ncbi.nlm.nih.gov/pubmed/31617624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903661
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