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Chemical Probes for the Functionalization of Polyketide Intermediates**
A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S. lasaliensis in the presence of the probes generated a range of unnatural polyk...
Gardado en:
| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
WILEY-VCH Verlag
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501312/ https://ncbi.nlm.nih.gov/pubmed/25212788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201407448 |
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