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Stem cell models of polyglutamine diseases and their use in cell-based therapies
Polyglutamine diseases are fatal neurological disorders that affect the central nervous system. They are caused by mutations in disease genes that contain CAG trinucleotide expansions in their coding regions. These mutations are translated into expanded glutamine chains in pathological proteins. Mut...
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| Veröffentlicht in: | Front Neurosci |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501170/ https://ncbi.nlm.nih.gov/pubmed/26236184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00247 |
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