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Stem cell models of polyglutamine diseases and their use in cell-based therapies
Polyglutamine diseases are fatal neurological disorders that affect the central nervous system. They are caused by mutations in disease genes that contain CAG trinucleotide expansions in their coding regions. These mutations are translated into expanded glutamine chains in pathological proteins. Mut...
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| Udgivet i: | Front Neurosci |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501170/ https://ncbi.nlm.nih.gov/pubmed/26236184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00247 |
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