Induced Pluripotent Stem Cells in Huntington’s Disease: Disease Modeling and the Potential for Cell-Based Therapy

Huntington’s disease (HD) is an incurable neurodegenerative disorder that is characterized by motor dysfunction, cognitive impairment, and behavioral abnormalities. It is an autosomal dominant disorder caused by a CAG repeat expansion in the huntingtin gene, resulting in progressive neuronal loss pr...

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Veröffentlicht in:Mol Neurobiol
Hauptverfasser: Liu, Ling, Huang, Jin-Sha, Han, Chao, Zhang, Guo-Xin, Xu, Xiao-Yun, Shen, Yan, Li, Jie, Jiang, Hai-Yang, Lin, Zhi-Cheng, Xiong, Nian, Wang, Tao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317136/
https://ncbi.nlm.nih.gov/pubmed/26659595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-015-9601-8
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