Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

BACKGROUND: Topical application of the synthetic triterpenoid RTA 408 to rodents elicits a potent dermal cytoprotective phenotype through activation of the transcription factor Nrf2. Therefore, studies were conducted to investigate if such cytoprotective properties translate to human dermal cells, a...

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Veröffentlicht in:BMC Dermatol
Hauptverfasser: Reisman, Scott A., Goldsberry, Angela R., Lee, Chun-Yue I., O’Grady, Megan L., Proksch, Joel W., Ward, Keith W., Meyer, Colin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501113/
https://ncbi.nlm.nih.gov/pubmed/26170027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12895-015-0029-7
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