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The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases

BACKGROUND: Demography and environmental adaptation can affect the global distribution of genetic variants and possibly the distribution of disease. Population heterozygosity of single nucleotide polymorphisms has been shown to decrease strongly with distance from Africa and this has been attributed...

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Vydáno v:BMC Genet
Hlavní autoři: Blair, Lily M., Feldman, Marcus W.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501093/
https://ncbi.nlm.nih.gov/pubmed/26170196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0239-3
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