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The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases

BACKGROUND: Demography and environmental adaptation can affect the global distribution of genetic variants and possibly the distribution of disease. Population heterozygosity of single nucleotide polymorphisms has been shown to decrease strongly with distance from Africa and this has been attributed...

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Publicado en:BMC Genet
Autores principales: Blair, Lily M., Feldman, Marcus W.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501093/
https://ncbi.nlm.nih.gov/pubmed/26170196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0239-3
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