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Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer

Inhibitors against the p110δ isoform of PI3K have shown remarkable therapeutic efficacy in some human leukaemias(1,2). Since p110δ is primarily expressed in leukocytes(3), drugs against p110δ have not been considered for the treatment of solid tumours(4). We report here that p110δ inactivation in mi...

詳細記述

保存先:
書誌詳細
出版年:Nature
主要な著者: Ali, Khaled, Soond, Dalya R., Pineiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501086/
https://ncbi.nlm.nih.gov/pubmed/24919154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13444
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