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Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer
Inhibitors against the p110δ isoform of PI3K have shown remarkable therapeutic efficacy in some human leukaemias(1,2). Since p110δ is primarily expressed in leukocytes(3), drugs against p110δ have not been considered for the treatment of solid tumours(4). We report here that p110δ inactivation in mi...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501086/ https://ncbi.nlm.nih.gov/pubmed/24919154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13444 |
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