Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer

Inhibitors against the p110δ isoform of PI3K have shown remarkable therapeutic efficacy in some human leukaemias(1,2). Since p110δ is primarily expressed in leukocytes(3), drugs against p110δ have not been considered for the treatment of solid tumours(4). We report here that p110δ inactivation in mi...

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Publicado en:Nature
Main Authors: Ali, Khaled, Soond, Dalya R., Pineiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501086/
https://ncbi.nlm.nih.gov/pubmed/24919154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13444
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