Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer

Inhibitors against the p110δ isoform of PI3K have shown remarkable therapeutic efficacy in some human leukaemias(1,2). Since p110δ is primarily expressed in leukocytes(3), drugs against p110δ have not been considered for the treatment of solid tumours(4). We report here that p110δ inactivation in mi...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Ali, Khaled, Soond, Dalya R., Pineiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501086/
https://ncbi.nlm.nih.gov/pubmed/24919154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13444
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