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Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
The activation of antigen receptors triggers two important signalling pathways originating from phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P(2)]. The first is phospholipase Cγ (PLCγ)-mediated hydrolysis of PtdIns(4,5)P(2), resulting in the activation of Ras, protein kinase C and Ca(2+) flux....
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier Science Ltd
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2358943/ https://ncbi.nlm.nih.gov/pubmed/17208518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2006.12.007 |
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