Observational infant exploratory [(14)C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis

AIMS: The aims of the study were to compare [(14)C]-paracetamol ([(14)C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0–2 year old age group....

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Garner, Colin R, Park, Kevin B, French, Neil S, Earnshaw, Caroline, Schipani, Alessandro, Selby, Andrew M, Byrne, Lindsay, Siner, Sarah, Crawley, Francis P, Vaes, Wouter H J, van Duijn, Esther, deLigt, Rianne, Varendi, Heili, Lass, Jane, Grynkiewicz, Grzegorz, Maruszak, Wioletta, Turner, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Paediatric Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500335/
https://ncbi.nlm.nih.gov/pubmed/25619398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12597
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