Integrative population pharmacokinetic and pharmacodynamic dose finding approach of the new camptothecin compound namitecan (ST1968)

AIMS: Namitecan is a new camptothecan compound undergoing early clinical development. This study was initiated to build an integrated pharmacokinetic (PK) and pharmacodynamic (PD) population model of namitecan to guide future clinical development. METHODS: Plasma concentration–time data, neutrophils...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Joerger, M, Hess, D, Delmonte, A, Gallerani, E, Fasolo, A, Gianni, L, Cresta, S, Barbieri, P, Pace, S, Sessa, C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Pk-Pd Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500332/
https://ncbi.nlm.nih.gov/pubmed/25580946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12583
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