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Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization
Stargardt disease, an ATP-binding cassette, subfamily A, member 4 (ABCA4)-related retinopathy, is a genetic condition characterized by the accelerated accumulation of lipofuscin in the retinal pigment epithelium, degeneration of the neuroretina, and loss of vision. No approved treatment exists. Here...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500285/ https://ncbi.nlm.nih.gov/pubmed/26106163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506960112 |
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