Allosteric interactions between agonists and antagonists within the adenosine A(2A) receptor-dopamine D(2) receptor heterotetramer

Adenosine A(2A) receptor (A(2A)R)-dopamine D(2) receptor (D(2)R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A(2A)R-D(2)R heteromer, by which adenosi...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Bonaventura, Jordi, Navarro, Gemma, Casadó-Anguera, Verònica, Azdad, Karima, Rea, William, Moreno, Estefanía, Brugarolas, Marc, Mallol, Josefa, Canela, Enric I., Lluís, Carme, Cortés, Antoni, Volkow, Nora D., Schiffmann, Serge N., Ferré, Sergi, Casadó, Vicent
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500251/
https://ncbi.nlm.nih.gov/pubmed/26100888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507704112
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