Allosteric interactions between agonists and antagonists within the adenosine A(2A) receptor-dopamine D(2) receptor heterotetramer

Adenosine A(2A) receptor (A(2A)R)-dopamine D(2) receptor (D(2)R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A(2A)R-D(2)R heteromer, by which adenosi...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Bonaventura, Jordi, Navarro, Gemma, Casadó-Anguera, Verònica, Azdad, Karima, Rea, William, Moreno, Estefanía, Brugarolas, Marc, Mallol, Josefa, Canela, Enric I., Lluís, Carme, Cortés, Antoni, Volkow, Nora D., Schiffmann, Serge N., Ferré, Sergi, Casadó, Vicent
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500251/
https://ncbi.nlm.nih.gov/pubmed/26100888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507704112
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