Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice

Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe neurological consequences. At present, the only recommended treatment of CCM is surgical. Because surgery is often not applicable, pharmacol...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Bravi, Luca, Rudini, Noemi, Cuttano, Roberto, Giampietro, Costanza, Maddaluno, Luigi, Ferrarini, Luca, Adams, Ralf H., Corada, Monica, Boulday, Gwenola, Tournier-Lasserve, Elizabeth, Dejana, Elisabetta, Lampugnani, Maria Grazia
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500248/
https://ncbi.nlm.nih.gov/pubmed/26109568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501352112
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items