Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts

The antidiuretic hormone arginine vasopressin is a systemic effector in urinary concentration. However, increasing evidence suggests that other locally produced factors may also play an important role in the regulation of water reabsorption in renal collecting ducts. Recently, prostaglandin E2 (PGE2...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Gao, Min, Cao, Rong, Du, Shengnan, Jia, Xiao, Zheng, Senfeng, Huang, Shizheng, Han, Qifei, Liu, Jia, Zhang, Xiaoyan, Miao, Yifei, Kang, Jihong, Gustafsson, Jan-Åke, Guan, Youfei
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500247/
https://ncbi.nlm.nih.gov/pubmed/26100911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509565112
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