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N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias
Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500229/ https://ncbi.nlm.nih.gov/pubmed/26100877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508838112 |
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