N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias

Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Soto, Antonio G., Smith, Thomas H., Chen, Buxin, Bhattacharya, Supriyo, Cordova, Isabel Canto, Kenakin, Terry, Vaidehi, Nagarajan, Trejo, JoAnn
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500229/
https://ncbi.nlm.nih.gov/pubmed/26100877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508838112
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