Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis

Understanding the mechanism by which cell growth, migration, polyploidy, and tumourigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2-macroH2A1 (mH2A1)-CDK8 axis as a critical pathway for these processes, and deregulation of this pathway...

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Pubblicato in:Nat Commun
Autori principali: Xu, Dazhi, Li, Chien-Feng, Zhang, Xian, Gong, Zhaohui, Chan, Chia-Hsin, Lee, Szu-Wei, Jin, Guoxiang, Rezaeian, Abdol-Hossein, Han, Fei, Wang, Jing, Yang, Wei-Lei, Feng, Zi-Zhen, Chen, Wei, Wu, Ching-Yuan, Wang, Ying-Jan, Chow, Lu-Ping, Zhu, Xiao-Feng, Zeng, Yi-Xin, Lin, Hui-Kuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500169/
https://ncbi.nlm.nih.gov/pubmed/25818643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7641
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