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Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis
Understanding the mechanism by which cell growth, migration, polyploidy, and tumourigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2-macroH2A1 (mH2A1)-CDK8 axis as a critical pathway for these processes, and deregulation of this pathway...
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Vydáno v: | Nat Commun |
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Hlavní autoři: | , , , , , , , , , , , , , , , , , , |
Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
2015
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500169/ https://ncbi.nlm.nih.gov/pubmed/25818643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7641 |
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