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Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
The immunosuppressant drug rapamycin blocks progression of the cell cycle at the G1 phase in mammalian cells and yeast. Here we show that rapamycin inhibits cap-dependent, but not cap-independent, translation in NIH 3T3 cells. Cap-dependent translation is also specifically reduced in extracts from r...
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| 發表在: | EMBO J |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
1996
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449984/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8599949/ |
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