Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells

DNA methylation is thought to induce transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators unable to bind their target sites when methylated, and the recruitment of transcriptional repressors with specific affinity for methylated DNA. The Me...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Devailly, Guillaume, Grandin, Mélodie, Perriaud, Laury, Mathot, Pauline, Delcros, Jean-Guy, Bidet, Yannick, Morel, Anne-Pierre, Bignon, Jean-Yves, Puisieux, Alain, Mehlen, Patrick, Dante, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499136/
https://ncbi.nlm.nih.gov/pubmed/26007656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv508
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