Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA

MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms contain two DNA-binding domains—an MBD, which recognizes methylated DNA; and a CXXC3 zinc finger, which binds unmethylated Cp...

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Hlavní autoři: Clouaire, Thomas, de las Heras, Jose Ignacio, Merusi, Cara, Stancheva, Irina
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919722/
https://ncbi.nlm.nih.gov/pubmed/20378711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq228
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