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Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms contain two DNA-binding domains—an MBD, which recognizes methylated DNA; and a CXXC3 zinc finger, which binds unmethylated Cp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919722/ https://ncbi.nlm.nih.gov/pubmed/20378711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq228 |
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