Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression

Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-responsiveness to growth inhibitory signals. Both genetic and epigenetic changes can contribute to cancer development and prog...

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Библиографические подробности
Главные авторы: Gordon, Katrina, Clouaire, Thomas, Bao, Xun X., Kemp, Sadie E., Xenophontos, Maria, de Las Heras, Jose Ignacio, Stancheva, Irina
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
Предметы:
Gene Regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973294/
https://ncbi.nlm.nih.gov/pubmed/24371281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1351
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